Methylome profile of leukemia already present in the precancerous stage
2021
Dana-Farber Cancer Institute, Boston, USA(1)
Max Planck Institute for Molecular Genetics, Berlin, Germany(2)
Max Planck Institute for Molecular Genetics, Berlin, Germany(2)
The study analyses DNA methylation data from a large cohort of patients with monoclonal B-cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL) and shows that epigenetic transformation emerges early and persists throughout disease stages with limited subsequent changes. The results indicate an early role for this aberrant methylome landscape in the normal-to-preneoplastic transition that may reflect a pan-cancer mechanism.
Preneoplastic alterations define CLL DNA methylome and persist through disease progression and therapy
Catherine J. Wu(1), Alexander Meissner(2)
Added on: 02-11-2021
[1] https://bloodcancerdiscov.aacrjournals.org/content/2/1/54[2] https://www.bionity.com/en/news/1169561/tracing-the-path-of-leukemia.html
