A human cornea model for replacing the Draize test
October 2018
Fraunhofer Translational Center Regenerative Therapies TLC-RT, Würzburg, Germany
The ImAi project, funded by the German Federal Ministry of Education and Research, aims to create an animal-free replacement method for the Draize test on rabbits used worldwide to assess the eye irritation potential of chemicals. The new test is based on laboratory-grown cornea tissue models and determines all three categories of eye irritation in one single test with an accuracy of 78 % and reproducibility of 88.9%. At the end of the project, a new standard procedure should be available that can be used worldwide.
Replacing the Draize eye test: Impedance spectroscopy as a 3R method to discriminate between all GHS categories for eye irritation
Christian Lotz
Added on: 11-23-2020
[1] https://www.nature.com/articles/s41598-018-33118-2[2] https://www.regenerative-therapien.fraunhofer.de/en/current-projects-and-news/project-launch-ImAi-replacing-worldwide-standard-animal-testing.html
