Microbiota transfer therapy in autistic children
October 2020
Arizona State University, Tempe, USA
Fecal microbiota transplant (FMT) is a promising therapy to repair dysbiotic gut microbiota. The authors previously performed intensive FMT called microbiota transfer therapy (MTT) for children with autism spectrum disorders and observed a substantial improvement of gastrointestinal and behavioural symptoms. This study presents comprehensive metabolite profiles from plasma and fecal samples of the children who participated in the MTT trial. With 619 plasma metabolites detected, the authors found that the autism group had distinctive metabolic profiles at baseline. In contrast, for 669 fecal metabolites detected, when correcting for multiple hypotheses, no metabolite was significantly different at baseline. MTT had a systemic effect, resulting in substantial changes in plasma metabolites, driving a number of metabolites to be more similar to those from typically developing children.
Distinct fecal and plasma metabolites in children with autism spectrum disorders and their modulation after microbiota transfer therapy
Rosa Krajmalnik-Brown, Dae-Wook Kang
Added on: 11-23-2020
[1] https://msphere.asm.org/content/5/5/e00314-20.full[2] https://www.bionity.com/en/news/1168693/managing-the-microbiome-raises-new-hope-for-autism.html
