Blood-brain barrier chips enable disease modeling
2019
The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, USA(1)
The Department of Physiology and Cell Biology and the Regenerative Medicine and Stem Cell (RMSC) Res, Be`er Sheva, Israel(2)
The Department of Physiology and Cell Biology and the Regenerative Medicine and Stem Cell (RMSC) Res, Be`er Sheva, Israel(2)
This iPSC-derived blood-brain barrier chip exhibits physiologically relevant transendothelial electrical resistance and accurately predicted blood-to-brain permeability of pharmacologics. Chips created from individuals with neurological diseases predicted disease-specific lack of transporters and disruption of barrier integrity.
Human iPSC-derived blood-brain barrier chips enable disease modeling and personalized medicine applications
Clive N. Svendsen(1), Gad D. Vatine(2)
Added on: 05-06-2020
[1] https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(19)30215-2?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1934590919302152%3Fshowall%3Dtrue[2] https://www.technologynetworks.com/neuroscience/news/blood-brain-barrier-recreated-outside-human-body-320370
