Light controlled cell‐cycle arrest and apoptosis
October 2020
Ludwig-Maximilians-Universität, Munich, Germany
Cell‐cycle interference by small molecules has widely been used to study fundamental biological mechanisms and to treat a great variety of diseases, most notably cancer. The study reports on a photocaging strategy to reversibly arrest the cell cycle at metaphase or induce apoptosis using blue light irradiation. This visible‐light responsive tool can be of great value for biological as well as medicinal approaches in need of high‐precision targeting of the proteasome and thereby the cell cycle and apoptosis.
Light controlled cell‐cycle arrest and apoptosis
Esther Zanin
Added on: 11-06-2020
[1] https://onlinelibrary.wiley.com/doi/10.1002/anie.202008267[2] https://www.bionity.com/en/news/1168481/photopharmacology-a-light-trigger-for-the-proteasome.html
