Brain model reveals neurotoxicological reactions to antidepressiva
2020
Center for Alternatives to Animal Testing (CAAT), Johns Hopkins Bloomberg School of Public Health, Baltimore, USA
Using human mini-brains (BrainSpheres), a selective serotonin reuptake inhibitor (SSRI), which is prescribed to pregnant women suffering from depression, has been shown to have a negative effect on the expression of synaptic markers, neurite growth and oligocyte population growth. It has been observed that the use of SSRI during pregnancy is related to neurological abnormalities such as autism in newborns and children. The results obtained with the BrainSpheres suggest that the substance may indeed impair brain development. Thus, the BrainSpheres represent a novel method for toxicity testing and identifying potential developmental neurotoxicants among chemicals and drugs before their entry to the market.
Antidepressant Paroxetine Exerts Developmental Neurotoxicity in an iPSC-Derived 3D Human Brain Model
David Pamies
Added on: 08-28-2020
[1] https://www.frontiersin.org/articles/10.3389/fncel.2020.00025/full
