Proteomics in a 3D bioprinted placenta
2018
Center for Engineering Complex Tissues, University of Maryland, College Park, USA
The placental basement membrane (BM) proteins (e.g. laminin, collagen) has been implicated in the development of placenta while the level of laminin is significantly lower in preeclampsia. The authors hypothesized that placental BM proteins are required for effective cytotrophoblast invasion. Using proteomics, the study finds that more than 80% of ECM (extracellular matrix) proteins in placental basal plate were BM proteins. Thus, the ECM microenvironment substantially regulates cytotrophoblast invasion, an area that is less investigated but appears to be critical in the pathogenesis of preeclampsia. Moreover, this model can be an attractive option to screen and develop novel therapeutics and biomarkers not only in preeclampsia but also other diseases such as cancer metastasis.
Placental basement membrane proteins are required for effective cytotrophoblast invasion in a 3d bioprinted placenta model
John P. Fisher
Added on: 07-09-2020
[1] https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.36350
