Chips simulate the tumor microenvironment
2013
Massachusetts Institute of Technology, Cambridge, USA
Cancer spheroid dispersion assays are used to mimic the epithelial-to-mesenchymal transition (EMT) that occurs in the early stages of cancer metastasis. Cancer spheroids can be seeded in 3D hydrogels on chips and cultivated together with secondary cell types (such as endothelial cells) to more accurately mimic the tumor microenvironment. The migration rates of cancer cells and other details of the process can be closely monitored in real-time to gain insight into the development of metastases, which are responsible for 90% of cancer-related deaths.
A 3D system of adenocarcinoma cell spheroids can be used for drug screening.
Screening therapeutic EMT blocking agents in a three-dimensional microenvironment
Roger D. Kamm
Added on: 07-09-2020
[1] https://academic.oup.com/ib/article-abstract/5/2/381/5204176?redirectedFrom=fulltext[2] https://aimbiotech.com/applications/spheroid-dispersion/
