Non Animal Testing Database
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New combined method for imaging neuronal brain activity

2019
Max Planck Institute for Human Development, Berlin, Germany(1)
Princeton University, Princeton, USA(2)
Participants' brains were studied by functional magnetic resonance imaging signals after they had learned a decision-making task. During a subsequent resting phase, the replay of activity patterns in the hippocampus reflected the order of previous task-state sequences at a higher speed. Thus, sequential hippocampal reactivation might participate in human decision-making. The results support the importance of sequential reactivation in the human hippocampus for nonspatial decision-making and establish the feasibility of investigating such rapid signals with fMRI (functional magnetic resonance imaging), despite substantial limitations in temporal resolution. To date, a non-invasive, human-based method to measure fast brain activities was lacking. By combining this MRI technique with an algorithm for the detection of activity pattern, a method was developed for studying human brain processes.
Sequential replay of nonspatial task states in the human hippocampus
Nicolas W. Schuck(1), Yael Niv(2)
#241
Added on: 07-09-2020
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