SARS-Cov-2 neurotropism in BrainSpheres
2020
Johns Hopkins University School of Medicine, Baltimore, USA
Reports from Wuhan suggest that 36% of COVID-19 patients show neurological symptoms, and cases of viral encephalitis have been reported, suggesting that the virus is neurotropic under unknown circumstances. The authors employ a human induced pluripotent stem cell (iPSC)-derived BrainSphere model, which has been previously used for Zika, Dengue, HIV and John Cunningham virus infection studies. The expression of the ACE2 receptor but not TMPRSS2 was detected in the model. The system allows both virus infection and replication, demonstrating the potential neurotropism of SARS-CoV-2.
Infectability of human BrainSphere neurons suggests neurotropism of SARS-CoV-2
Lena Smirnova
Added on: 07-07-2020
[1] https://www.altex.org/index.php/altex/article/view/1924
