3D vessel-on-chip model for research into vascular diseases
CompanyDynamic42 GmbH, Jena, Germany
The three-dimensional vessel-on-chip model from Dynamic42 validly recapitulates the structural and functional properties of vascular vessels in the human bloodstream. The microfluidic platform contains human endothelial cells and optionally tissue-resident macrophages, and enables the inclusion of circulating immune cell populations. For an increased complexity, the models can also be equipped with other vascular cell types, such as smooth muscle cells and fibroblasts. The speed and flow rate of blood can be controlled and adjusted to the required conditions. The perfused organ chip can be powered by various cell sources and creates a stable physiological microenvironment for up to 7 days. The model can be used in different studies. It is suitable for disease modelling and evaluating the efficacy and toxicity of preclinical drug candidates and other chemicals administered intravenously. It is also suitable for studying the interactions between vascular cells and the cells of the immune system or medications circulating in the blood. In summary, the method can help to accelerate drug development, optimize existing therapeutic approaches and generate new insights into pathological mechanisms at the cellular level.
Vasculature-on-chip
info@dynamic42.com
Added on: 04-05-2024
[1] https://dynamic42.com/vasculature-on-chip/
