How successive mRNA vaccines shape T-cell memory
2024
Tokyo University of Science, Noda City, Japan
mRNA vaccines against the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) elicit strong T cell responses. Here, the researchers conducted a longitudinal analysis on peripheral T cells of 38 participants who has received the Pfizer vaccine from before the vaccine to after the third vaccination. The results showed a shift in T cell responses between clone types with different kinetics: from early responders, which expand rapidly after the first vaccination, to main responders, which expand strongly after the second vaccination. Although the main responders re-spread after the third vaccination, their clonal diversity was distorted and newly triggered third responders partially replaced them. Moreover, this shift in clonal dominance occurred not only between, but also within clonal types specific for spike epitopes. The results indicates that T cells can ‘re-write’ themselves and reshape their memory populations after successive vaccinations, which can help to understand vaccine-induced T cell responses in general.
CD8+ T cell memory induced by successive SARS-CoV-2 mRNA vaccinations is characterized by shifts in clonal dominance
Satoshi Ueha
Added on: 04-02-2024
[1] https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00215-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124724002158%3Fshowall%3Dtrue[2] https://www.drugtargetreview.com/news/142674/how-successive-mrna-vaccines-shape-t-cell-memory/
