Influence of glucocorticoids on microglia development
December 2022
University College London Institute of Neurology, London, United Kingdom
Prenatal exposure to glucocorticoids (GC) results in a higher risk of psychiatric and neurodevelopmental disorders in later life. In this study, induced pluripotent stem cells (iPSCs) were generated from fibroblasts derived from patients and healthy individuals. iPSCs were exposed to GC during early differentiation into microglia, and it was examined how this exposure affected the microglial phenotype using RNA-seq analyses and functional assays.
The in vitro model allows the investigation of the responses of microglia in the pathogenesis of prenatal GC- exposure-associated disorders such as schizophrenia, attention-deficit hyperactivity disorder and autism spectrum disorder.
Human myeloid progenitor glucocorticoid receptor activation causes genomic instability, type 1 IFN- response pathway activation and senescence in differentiated microglia; an early life stress model
Thomas M. Piers, Jennifer M. Pocock
Added on: 10-26-2023
[1] https://onlinelibrary.wiley.com/doi/10.1002/glia.24325
