Clinical study on the use of insulin pumps and skin pathologies
2023
University of Washington, Seattle, USA
Here, the researchers shed light on the issue that some diabetes type I patients suffer from fibrotic, irritated insulin pump sites on their skin that become less effective at delivering insulin. The study involved 30 participants and aimed to answer key questions surrounding the skin pathology caused by long-term pump usage. Using noninvasive optical methods and skin biopsies, the authors evaluated skin changes from chronic insulin infusion. Surprisingly, the researchers found no significant difference in skin pathology between the group of short-term users (10 years or less) and long-term users (over 20 years). The analysis of pump sites showed differences in skin architecture, including fibrosis, inflammation, and fat necrosis. These findings support allergic sensitization as a potentially common reaction at pump sites. The leading candidates causing this include insulin preservatives, plastic materials, and adhesive glue used in device manufacturing. The inflammatory response caused by these common allergic responses may result in tissue changes responsible for the infusion site failures seen frequently in clinical practice.
Evaluation of insulin pump infusion sites in type 1 diabetes: the DERMIS study
Irl B. Hirsch
Added on: 09-14-2023
[1] https://diabetesjournals.org/care/article-abstract/46/9/1626/153369/Evaluation-of-Insulin-Pump-Infusion-Sites-in-Type[2] https://www.drugtargetreview.com/news/111071/unlocking-the-achilles-heel-of-insulin-pump-technology/?utm_source=Email+marketing&utm_medium=email&utm_campaign=DTR+-+Industry+Insight+-+Quantum+-+01.09.2023&utm_term=Computational+tool+gets+more+out+of+multi-omics+data&utm_content=https%3a%2f%2femails.drugtargetreview.com%2frussellpublishinglz%2f&gator_td=mIEcIc9i81kCKVEhzhGoua2AdBgsh3MXlma4DaxbM%2bxK7rKyR%2fQcxk8ybkHB1l%2bRXEvytgBCnnivdmqswbwYTxn4iGykbFmGXXK7dz8FnJzV82Okhr4PBfh1smePTncFC5cYRgtu%2f2Az8umlaHaYwOrkQf3awJMA0VuCviYYObU2xCPqj4rl%2b6sSM5T5exVI%2fzk%2b0uf1Z1EzIpnMw8X8kEumOE8bMB8%2f1hAmVz6Yx%2fw%3d
