Low-cost optical system for cardiac electrophysiology
2023
George Washington University, Washington, USA
All-optical cardiac electrophysiology enables the visualization and control of key parameters relevant to the detection of cardiac arrhythmias. Mapping such responses in human induced pluripotent stem-cell-derived cardiomyocytes (hiPSC-CMs) is of great interest for cardiotoxicity and personalized medicine applications. Here, the researchers introduce and validate a very low-cost compact mapping system for macroscopic all-optical electrophysiology in layers of hiPSC-CMs. As multiple optical sensors and actuators are combined, the results can help handle the “spectral congestion” and avoid parameter distortion. The authors illustrate the utility of the system for uncovering the action of cellular uncoupling agents and show extensibility to an epi-illumination mode for future imaging of thicker native or engineered tissues.
Portable low-cost macroscopic mapping system for all-optical cardiac electrophysiology
Emilia Entcheva
Added on: 09-14-2023
[1] https://www.spiedigitallibrary.org/journals/journal-of-biomedical-optics/volume-28/issue-01/016001/Portable-low-cost-macroscopic-mapping-system-for-all-optical-cardiac/10.1117/1.JBO.28.1.016001.full?SSO=1[2] https://www.drugtargetreview.com/news/107901/researchers-develop-an-all-optical-system-for-testing-lab-on-a-chip-human-hearts/?utm_source=Email+marketing&utm_medium=email&utm_campaign=DTR+-+Industry+Insight+-+Catalent+-+IPSC+-+12.05.2023&utm_term=Researchers+develop+an+all-optical+system+for+testing+lab-on-a-chip+human+hearts&utm_content=https%3a%2f%2femails.drugtargetreview.com%2frussellpublishinglz%2f&gator_td=cJEdbYCBJJPKWf%2f9%2fmayhg%2bx9IDJaLyhbGBeClkBl8gTg%2fY32U1xwQ%2f9GGSOqUTPjVq%2fyw7UvQj3cXGcmtg%2bHZy%2fyYsAPvaOeaIFHy8xq2KOZfTN6Hyv0L1aICyVJ%2bv2%2fo%2bsEkSrWyPC6bliFnD%2b9mOiJuZwTXIMuILEgTxjXHHMj38WCgD7CP3q%2f%2b%2fAq1Nmm5Qsy5ToGIF3Rfl6PaG8U%2f4koaEgbQbdxLN3ew4%2bpjMpHThtqaOHqbs6caHhAIUg
