3D-printed tumor microvasculature
2023
University of Strathclyde, Glasgow, United Kingdom
Many solid tumors form a disorganized neo-vasculature to support tumor growth. In this study, a novel approach to develop multi-material tissue-mimicking, cell-compatible platforms able to represent the complexity of a solid tumor’s neo-vasculature is investigated via stereolithography three-dimensional printing.
A series of hydrogels, mimicking healthy and diseased tissue properties, are designed and characterized. The hydrogels are exploited to produce a simplified multi-material three-dimensional printed model of the neo-vasculature of a solid tumor. The applicability of these materials in preclinical research is assessed by studying the morphology, actin expression, focal adhesions and nitric oxide release of human umbilical vein endothelial cells.
Investigating multi-material hydrogel three-dimensional printing for in vitro representation of the neo-vasculature of solid tumours: a comprehensive mechanical analysis and assessment of nitric oxide release from human umbilical vein endot
Roger Domingo-Roca
Added on: 09-11-2023
[1] https://royalsocietypublishing.org/doi/10.1098/rsos.230929
