In silico trial to test COVID-19 candidate vaccines
2020
University of Catania, Catania, Italy
The application of in silico trials can be used for designing and testing medicines against SARS-CoV-2 and speed-up the vaccine discovery pipeline, predicting any therapeutic failure and minimizing undesired effects. The presented in silico platform showed to be in very good agreement with the latest literature in predicting SARS-CoV-2 dynamics and related immune system host response. Moreover, it has been used to predict the outcome of one of the latest suggested approaches to design an effective vaccine, based on a monoclonal antibody. The Universal Immune System Simulator (UISS) in silico platform is potentially ready to be used as an in silico trial platform to predict the outcome of vaccination strategy against SARS-CoV-2.
In silico trial to test COVID-19 candidate vaccines: a case study with UISS platform
Francesco Pappalardo
Added on: 06-25-2020
[1] https://www.biorxiv.org/content/10.1101/2020.05.06.080630v1.full
