Cellular atlas of the maternal-fetal interface
2023
Stanford University, Stanford, USA
This study aims to map the cellular interface between the placenta and the uterus in order to understand how cells from the fetus invade and remodel blood vessels in the lining of the uterus to ensure nutrient supply of the growing embryo.
500,000 cells from 588 uterine arteries derived from 66 individuals were analysed in a multi-omics approach. The derived spatiotemporal atlas of the human maternal-fetal interface will allow a deeper understanding of complications during pregnancy. Moreover, as many of the pathways involved in formation of the maternal-fetal interface are also involved in tumor progression, this atlas may help to understand how immune tolerance, tissue remodelling and angiogenesis are altered in cancer.
A spatially resolved timeline of the human maternal–fetal interface
Michael Angelo, Shirley Greenbaum
Added on: 08-21-2023
[1] https://www.nature.com/articles/s41586-023-06298-9#Sec7[2] https://www.nih.gov/news-events/nih-research-matters/cell-atlases-give-detailed-views-human-organs
