Human protein-based hydrogel solutions for creating physiological microenvironments
CompanyMetatissue, Ílhavo, Portugal
The company Metatissue specializes in the production of human, protein-based and chemically modified bioproducts for the development of three-dimensional in vitro microenvironments (hydrogels, sponges, bioinks). The PLMA photopolymerizable hydrogels are based on certain enzymes of the blood platelets (platelet lyases), whose bioactivity produces relevant proteins, cytokines and growth factors for mimicking a physiological, extracellular environment. The variable concentration of the PLMA 100 lyophilisate in the precursor solution and control of the gelation time enable the mechanical properties of the hydrogel to be modulated to suit individual research purposes. PMLA 100 can be used to cultivate various cells such as human stem cells (hSCs) or cancer cells (MG-63, SaOS-2 and A549). The hydrogel solutions enable tissue-specific modelling of a three-dimensional, bioactive extracellular environment in which the cultured cells are supplied with sufficient "nutrients" for relevant cell adhesion and proliferation processes over a period of up to 2 weeks. Metatissue's xeno-free hydrogels can help to improve the simulation and research of certain clinical pictures and thus (personalized) drug development by closely resembling the physiological conditions in vivo.
Human-based products for cell culture und tissue engineering
info@metatissue.com
Added on: 08-03-2023
[1] https://metatissue.com/products/
