Perfused multi-organ panel for drug and tumor research
CompanyLena Biosciences, Atlanta, USA
Lena Biosciences has developed an organ panel (POP) that enables blood-like perfusion of cultured tissue in vitro. The microphysiological system consists of a multi-well plate (PerfusionPal) that is placed in a tray in which the cell cultures are independently perfused with a specially developed synthetic blood substitute. An integrated pump system enables simultaneous and controlled perfusion of up to 96 cell cultures. The blood-substitute contains a hemoglobin analogue, which ensures adequate oxygenation of the micro-tissues and stabilizes the pH of the cell medium. The blood substitute is immiscible with media, drugs or other reagents and can be collected after the experiment, sterile filtered and then reused for new studies. For the optimal development of microtissues and their long-term culture, the company has developed special cell culture scaffolds (SeedEZ) made of inert glass microfibers, whose pore systems allow the unhindered transport of nutrients, gases and metabolites, thus maintaining the physiological cell functions. The POP platform is suitable for conducting drug studies and for researching short-term and long-term metabolic interactions. In addition, the model can help improve cancer research by simulating vascularized tumors and their cellular environment.
Perfused organ panel
www.lenabio.com
Added on: 07-27-2023
[1] https://www.lenabio.com/perfused-organ-panel1.html
