In-silico trial of aneurism treatment
2021
University of Leeds, Leeds, United Kingdom
In-silico trials rely on virtual populations and interventions simulated using patient-specific models. In this study, a performance evaluation of so-called flow diverters, which are stents used to treat aneurysms, has been carried out. The study includes intracranial aneurysms of 164 virtual patients with 82 distinct anatomies under normotensive and hypertensive conditions. Computational fluid dynamics was used to quantify flow reduction after treatment with a flow-diverting stent.
The predicted flow-diversion success rates replicate the values previously reported in three clinical trials. Moreover, the model allows to perform virtual experiments and sub-group analyses to discover new insights on treatment failure, e.g. in the presence of side-branches or hypertension.
Finally, the model holds the potential to assess individual patients risks of complications and treatment failure and could support clinical decisions.
In-silico trial of intracranial flow diverters replicates and expands insights from conventional clinical trials
Alejandro F. Frangi
Added on: 07-14-2023
[1] https://www.nature.com/articles/s41467-021-23998-w[2] https://www.nc3rs.org.uk/news/international-3rs-prize-celebrates-animal-free-research#HC
