Colon model for microbiome research
2022
McGill University, Montreal, Canada
In this study, the Mini Colon Model (MiCoMo) is presented as a low-cost, benchtop multi-bioreactor system that simulates the human colon environment with physiologically relevant conditions. The device consists of three bioreactors working independently, an anaerobic chamber, and is equipped with automated pH, temperature, and fluidic control.
MiCoMo was inoculated with faecal samples derived from four healthy volunteers and was shown to be able to support a complex microbiota community over the experimental duration of 14 days. Moreover, the system retained inter-sample microbial differences.
Given the low cost and ease of operation, MiCoMo is believed to be a suitable tool to study gut microbial communities as well as to conduct individualized human gut microbiota studies.
The mini colon model: a benchtop multibioreactor system to investigate the gut microbiome
David Juncker, Corinne F. Maurice
Added on: 04-25-2023
[1] https://www.tandfonline.com/doi/full/10.1080/19490976.2022.2096993
