Genome-wide screening identifies genes for amyloid beta peptide toxicity
2023
Universitat Pompeu Fabra, Barcelona, Spain
Alzheimer’s disease (AD) is known to be caused by amyloid β-peptide (Aβ) misfolded into β-sheets, but this knowledge has not yet led to treatments to prevent AD. To identify novel molecular players in Aβ toxicity, the researchers carried out a genome-wide screen in Saccharomyces cerevisiae, using a library of 5154 gene knock-out strains expressing Aβ1–42. They identified 81 mammalian orthologous genes that enhance Aβ1–42 toxicity, while 157 were protective. The most affected cellular functions were calcium regulation, protein translation and mitochondrial activity. In summary, the authors identified new enhancer and protective activities for Aβ toxicity and showed that SURF4 contributes to Aβ1–42 neurotoxicity by decreasing store-operated calcium channel (SOCE) activity.
A genome-wide functional screen identifies enhancer and protective genes for amyloid beta-peptide toxicity
Francisco J. Muñoz
Added on: 04-25-2023
[1] https://www.mdpi.com/1422-0067/24/2/1278[2] https://www.drugtargetreview.com/news/108847/new-genes-modulate-toxicity-of-the-protein-that-causes-alzheimers/?utm_source=Email+marketing&utm_medium=email&utm_campaign=DTR+-+Newsletter+12+-+Unsponsored+Newsletter+-+30.03.2023&utm_term=The+immune+systems+power+over+antibiotics+for+infections&utm_content=https%3a%2f%2femails.drugtargetreview.com%2frussellpublishinglz%2f&gator_td=sEiFUUaL2UYtXulcwFbLm7BXBIETHHTc0mur88phiicC8dB1pLyWH4l%2feNfuugSBg0u2G3SpOM8R5rt7uRdtMB%2fDbfiAjRy1ZH6jSbn%2b6n%2f55b7TQyQM%2fN8VG1%2fjh%2fZDiF7BVcTO2vh4ViYz8LKP68zdXEyf0g%2fx8TfUIiqZ0D4dZ15viLwQ3Puc3xoRgmTNbMLnYZWJjglDOtEvXT4bmoWBoGdnAIjn6ZAiploNYTHPsArn8Q%2f7b5c8Ljih5dz0
