3D screening model for cervical cancer drugs
2023
Oregon State University, Corvallis, USA
Cervical cancer is the second leading cause of cancer-related death in women under 40 and is one of the few cancers to have an increased incidence rate and decreased survival rate over the last 10 years. However, the development of new anticancer drugs remains a challenge. To facilitate the identification of novel and effective anticancer drugs for cervical cancer, the researchers developed a 3D multilayer multicellular platform of human cervical cancer cell lines and primary human microvascular endothelial cells. The model is suitable for high throughput drug screening methods to evaluate the anti-metastatic and anti-angiogenic drug efficacy simultaneously. Using this platform, the researchers conducted a targeted drug screen of four clinically relevant drugs on two cervical cancer cell lines. Overall, this work provides a valuable platform that can be used to screen large compound libraries for mechanistic studies, drug discovery, and precision oncology for cervical cancer patients.
Engineering high throughput screening platforms of cervical cancer
Kaitlin C. Fogg
Ines A. Cadena et al. Journal of Biomedical Materials Research Part A 2023 [1]
Drug Target Review [2]
Added on: 04-25-2023
[1] https://onlinelibrary.wiley.com/doi/10.1002/jbm.a.37522[2] https://www.drugtargetreview.com/news/109085/researchers-develop-screening-model-to-evaluate-potential-cervical-cancer-drugs/?utm_source=Email+marketing&utm_medium=email&utm_campaign=DTR+-+Newsletter+13+-+Unsponsored+-+06.04.2023&utm_term=The+role+of+ABCs+in+lupus%3a+insights+for+developing+precision+therapies&utm_content=https%3a%2f%2femails.drugtargetreview.com%2frussellpublishinglz%2f&gator_td=KadJ7NhNMflA%2f%2fH3s0ldgEIo0FCHAEzCPC2%2bsRjZlh1UD9Hi2t%2bDARGahgwT4BjJKc1cOqh%2b0yvo3urrCygWulx0zfdtOc18lyGl1oh%2bjsDorii86pwnzquFDipS4v4u4NkgWW3vlI4TPvuLipct%2bH9b5Ww9Yx7URZHehLaAUGfqD9R%2fV%2bvk5Fi1wQmM4RmbfVEKXKnUEFwN2pwDimKtWfZ7WVlUUxiXe9cdecygf0Ol%2b9H9IunJ36FZGlrqzaDz
