Vascularized glioblastoma on a chip
2021
University of Technology Sydney, Sydney, Australia
In this study, a 3D vascularized glioblastoma on-a-chip model has been developed by combination of a microfluidic system and 3D bioprinting. Glioblastoma cells and endothelial cells were printed separately into the tissue compartment of the device using distinct hydrogels as bioinks. The tissue compartment was surrounded by a circular vascular channel which was separated from the tissue compartment via a porous membrane. Endothelial cells were seeded into the vascular channel, resulting in a functional blood-brain-barrier. The model was tested under microgravity conditions resulting in a significant cell morphological response.
The glioblastoma-on-a-chip model could represent a meaningful biological tool for research in cancer mechanobiology and preclinical research in brain tumor therapy.
A 3D-bioprinted vascularized glioblastoma-on-a-chip for studying the impact of simulated microgravity as a novel pre-clinical approach in brain tumor therapy
Joshua Chou
Added on: 04-05-2023
[1] https://onlinelibrary.wiley.com/doi/full/10.1002/adtp.202100106
