Microstructural alterations in Alzheimer´s disease
October 2022
Karolinska Institute, Stockholm, Sweden
The goal of this study was to investigate neurodegeneration of the human cholinergic system using diffusion-weighted magnetic resonance imaging (MRI) across different stages of Alzheimer’s disease.
Therefore microstructural alterations of two major cholinergic pathways were investigated in individuals along the Alzheimer’s disease continuum using an in vivo model of the human cholinergic system based on neuroimaging. 402 participants, including patients with different stages of Alzheimer’s disease and healthy controls, were included in the study. In addition to MRI participants performed neuropsychological tests and cerebrospinal fluid biomarkers were analyzed.
Cholinergic white matter pathways were modelled with an enhanced diffusion neuroimaging pipeline and compared between the different stages of Alzheimer’s disease and in relation to cognitive performance.
Cholinergic white matter pathways along the Alzheimer’s disease continuum
Daniel Ferreira
Added on: 03-20-2023
[1] https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awac385/6775152?login=false
