Deeper understanding of cellular interaction between neutrophils and blood vessels
2017
University of Minnesota, Minneapolis, USA
A gel scaffold is constructed on a microfluidic device in microchambers, in which stable chemical gradients can be generated so that migration is stimulated in cells; these can also be quantified. A new finding is that the migration of neutrophils reduces the effect of a drug that inhibits endothelial migration.
It shows the complicated cellular interactions between endothelial cells and neutrophils: Endothelial migration highly sensitively regulates neutrophil migration, while the presence of neutrophils stabilizes the structures required for endothelial migration.
Endothelial cell migration is an essential component of angiogenesis, therefore it is involved in wound healing, tissue growth and reproductive organ development, among other things. In addition, endothelial cell migration could play a crucial role in many diseases characterized by over-profiling of blood vessels, such as cancer, arthritis, atherosclerosis and cardiovascular diseases.
The system enables a deeper understanding of the dynamic cellular interaction between neutrophils and endothelial cells and the pathogenesis of diseases.
A versatile microfluidic platform for the study of cellular interactions between endothelial cells and neutrophils
Christy Haynes
Added on: 05-29-2020
[1] https://www.sciencedirect.com/science/article/abs/pii/S0304416517300569
