3D tissue models for screening of neuroprotective compounds in Alzheimer's
2022
Tufts University, Medford, USA
Here, the researchers describe the use of 2D and 3D tissue culture models of herpesvirus-induced Alzheimer's Disease (AD), which recapitulate hallmark disease features of plaque formation, gliosis, neuroinflammation, and impaired neuronal signalling. They used these models to screen a panel of 21 medications, supplements, and nutraceuticals with purported neuroprotective benefits. This screen identified green tea catechins and resveratrol as having strong anti-plaque properties, functional neuroprotective benefits, and minimal neurotoxicity, providing support for their further investigation as AD preventives and therapies. Two other candidates, citicoline and metformin, reduced plaque formation and were minimally toxic, but did not protect against virus-induced impairments in neuronal signalling. This study establishes a simple platform for rapidly screening and characterizing AD compounds of interest in 2D and 3D human cortical tissue models representing physiologically relevant disease features.
Screening neuroprotective compounds in herpes-induced Alzheimer's disease cell and 3D tissue models
David L. Kaplan
Added on: 01-05-2023
[1] https://www.sciencedirect.com/science/article/pii/S0891584922001770?via%3Dihub[2] https://www.drugtargetreview.com/news/106490/green-tea-and-resveratrol-could-be-the-next-step-for-alzheimers-disease-research/
