Mechanistic insight into why women are more likely to get Alzheimer’s
December 2012
Massachusetts Institute of Technology, Cambridge, USA(1)
The Scripps Research Institute, La Jolla, USA(2)
The Scripps Research Institute, La Jolla, USA(2)
Protein S-nitros(yl)ation (SNO) is a post-translational modification involved in diverse processes in health and disease and can contribute to synaptic damage in Alzheimer’s disease (AD). To identify SNO proteins in AD brains, the researchers used mass spectrometry and analysed 40 postmortem AD and non-AD human brains from patients of both sexes. Increased S-nitrosylated complement component 3 (C3 ) levels were present in female over male AD brains. Mechanistically, they showed that the formation of SNO-C3 leads to increased synaptic phagocytosis, synapse loss and consequent cognitive decline. The study demonstrates robust alterations in the S-nitrosoproteome that contribute to AD pathogenesis in a sex-dependent manner.
Mechanistic insight into female predominance in Alzheimer’s disease based on aberrant protein S-nitrosylation of C3
Steven R. Tannenbaum(1), Stuart A. Lipton(2)
Added on: 01-05-2023
[1] https://www.science.org/doi/10.1126/sciadv.ade0764[2] https://www.drugtargetreview.com/news/107389/why-are-women-more-likely-to-get-alzheimers/
