3D cancer model for the analysis of tumor microenvironment
2018
Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain(1)
John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, USA(2)
John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, USA(2)
The authors developed a 3D co-culture model of lung adenocarcinoma cells and macrophages in an interpenetrating network hydrogel. The study shows that the presence of tumor-associated macrophages and the extracellular matrix (ECM) stiffness jointly contribute to an invasive phenotype and modulate the expression of key epithelial-to-mesenchymal transition (EMT)-related markers. The study demonstrates the utility of in vitro 3D cancer models suitable for interactions analyses in the tumor microenvironment.
Matrix stiffness and tumor-associated macrophages modulate epithelial to mesenchymal transition of human adenocarcinoma cells
Maria de la Fuente(1), David J. Mooney(2)
Added on: 04-21-2020
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904839/
