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Analyses of human midbrain tissues reveal Parkinson's disease mechanisms

December 2021
University of Luebeck, Luebeck, Germany(1)
University of Luxembourg, Luxembourg, Luxembourg(2)
Parkinson’s disease is characterized by a progressive loss of dopaminergic neurons, but the involved mechanisms remain largely unknown. A large genome-wide association study assessed the cell type-specific risk for Parkinson’s disease. Using post-mortem midbrain samples of patients, the contribution of all cell types was analysed by single-nuclei RNA sequencing. The same tissues were immunolabelled for validation of the outcomes. A specific neuronal cell cluster was identified as being exclusively present in Parkinson’s disease midbrains.
Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state
Malte Spielmann(1), Anne Grünewald(2)
#1656
Added on: 12-06-2022
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