Pain perception in a human model of peripheral nerves
2021
Queen’s University Belfast, Belfast, United Kingdom
Mas-related G-protein-coupled receptor X1 (MrgprX1) is human-specific and its expression is restricted to primary sensory neurons. However, its role in nociception and pain signalling pathways is largely unknown. This study aims to investigate the role of MrgprX1 in nociception via interaction with the pain receptor, Transient Receptor Potential Ankyrin 1 (TRPA1), using in-vitro and in-vivo human neuronal models. Results showed that MrgprX1 activates TRPA1 and induces membrane depolarization in a TRPA1-dependent manner. In addition, MrgprX1 sensitizes TRPA1 to agonist stimulation via Protein Kinase C (PKC). The activation and sensitization of TRPA1 by MrgprX1 in a model of human nerves suggests an important role for this receptor in the modulation of nociception.
Endogenous Mas-related G-protein-coupled receptor X1 activates and sensitizes TRPA1 in a human model of peripheral nerves
Ikhlas El Karim
Added on: 12-02-2022
[1] https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202001667RR
