Maternal autoantibody profiles as biomarkers for autism
2022
University of California, Davis, USA
Maternal autoantibody-related autism spectrum disorder (MAR ASD) is a subtype of autism in which pathogenic maternal autoantibodies (IgG) cross the placenta, access the developing brain, and cause neurodevelopmental alterations and behaviours associated with autism in the exposed offspring. The aim of this study was to validate previously identified MAR ASD patterns and their accuracy in predicting ASD risk in a prospective cohort employing maternal samples collected prior to parturition. The researchers used prenatal plasma from mothers of autistic children with or without co-occurring intellectual disability, intellectual disability without autism and general population controls. They found reactivity to one or more of nine previously identified MAR ASD patterns in 10% of the ASD group, demonstrating that the MAR ASD patterns could be used to assess ASD risk prior to symptom onset. Prenatal screening for these MAR patterns may lead to earlier identification of ASD and facilitate access to the appropriate early intervention services based on each child’s needs.
Maternal autoantibody profiles as biomarkers for ASD and ASD with co-occurring intellectual disability
Judy Van de Water
Added on: 11-28-2022
[1] https://www.nature.com/articles/s41380-022-01633-4[2] https://www.drugtargetreview.com/news/104193/a-new-study-sheds-light-onto-maternal-autoantibody-linked-to-autism/?utm_source=Email+marketing&utm_medium=email&utm_campaign=DTR+-+Industry+Insight+-+Fusion+Antibodies+-+Antibodies+-+29.07.22&utm_term=How+to+select+the+best+combination+of+antibodies+to+treat+HIV&utm_content=https%3a%2f%2femails.drugtargetreview.com%2frussellpublishinglz%2f&gator_td=tCWdylyMr%2f90F%2fbBvRIVOYCNOufMxRhAaHPPx%2bQNVIHhUxjnBWNagb9HxuTqJlPO1VG%2blWPaPMQ95qTKCqJZDjx0STPo317UQLTn2RmYLv80gIMYNIom4hRXM3azsENmzz66lNQw%2f6%2ff3b%2b4KsVEoCmIblw4575RC%2buSotfg5Z%2blQ7vLqxZqxmCF2TUcVBofmntb3Y9X%2bem7z5PpHwrQoIE9edkzM1jNiZWTFYfHPXcGwurLuCvldwqxto5DIlX1JPdHCQVyHP1PBO%2bWrkasqg%3d%3d
