Chlamydia and HPV co-infection in patient-derived ectocervix organoids
2022
Max Planck Institute for Infection Biology, Berlin, Germany
Coinfections with pathogenic microbes continually confront cervical mucosa, yet their implications in pathogenesis remain unclear. Lack of in vitro models recapitulating cervical epithelium has been a bottleneck to study coinfections. Using patient-derived ectocervical organoids, the researchers systematically modelled individual and coinfection dynamics of Human papillomavirus (HPV)16 and Chlamydia, associated with carcinogenesis. Organoids modelling HPV16 infection develop the characteristics of precancerous lesions while retaining the self-renewal capacity and organise into mature stratified epithelium similar to healthy organoids. HPV16 interferes with Chlamydia development and induces persistence. Strikingly, Chlamydia impedes HPV-induced mechanisms that maintain cellular and genome integrity, including mismatch repair in the stem cells. This study demonstrates the hazard of multiple infections and the unique cellular microenvironment they create, potentially contributing to neoplastic progression.
Modelling Chlamydia and HPV co-infection in patient-derived ectocervix organoids reveals distinct cellular reprogramming
Cindrilla Chumduri
Added on: 11-28-2022
[1] https://www.nature.com/articles/s41467-022-28569-1[2] https://www.drugtargetreview.com/news/101674/study-highlights-possibility-of-using-3d-organoids-of-the-cervix-to-test-drugs/?utm_source=Email+marketing&utm_medium=email&utm_campaign=DTR+-+Industry+Insight+-+Bio-Techne+-+Organoids+-+06.05.22&utm_term=Scientists+create+brain+organoids+to+understand+autism&utm_content=https%3a%2f%2femails.drugtargetreview.com%2frussellpublishinglz%2f&gator_td=iX%2fmyVj91S%2bc2AyEjDjndS54EdMTesGaKMuZ4EfTMrjCZqIuHPp1NM%2fECg5vRjnqMeg1VwiF075MHH6op2UThSOimHJsibguToBpnlqGrJznkyrQdg1%2fDMZDirmrtFJgxPyhWvSPENn%2fp7nYv%2fU%2fLx%2bvc3yGDLX7GhCLAciG1lj0V5zG9qjyGhjpi6J%2fc3IF13KIVtlA971fX68r7kTc5dz99cRPLSa3Rv1yzyQ%2fpyZXASq%2b0KH9q4IijF74RVvN
