Assessing astrocyte reactivity using neural organoids
2022
Houston Methodist Research Institute, Houston, USA
Astrocyte reactivity can directly modulate nervous system function and immune responses during disease and injury. However, the consequence of human astrocyte reactivity in response to specific contexts and within neural networks is obscure. Here, the researchers devised a straightforward bioengineered neural organoid culture approach entailing transcription factor-driven direct differentiation of neurons and astrocytes from human pluripotent stem cells combined with genetically encoded tools for dual cell-selective activation. Altogether, this study clarifies the intrinsic reactivity of human astrocytes in response to targeting GPCRs and delivers a bioengineered approach for organoid-based disease modelling and preclinical drug testing.
Assessing Gq-GPCR–induced human astrocyte reactivity using bioengineered neural organoids
Robert Krencik
Added on: 11-28-2022
[1] https://rupress.org/jcb/article/221/4/e202107135/212997/Assessing-Gq-GPCR-induced-human-astrocyte[2] https://www.drugtargetreview.com/news/102938/brain-organoids-may-boost-drug-screening-for-neurological-disorders/?utm_source=Email+marketing&utm_medium=email&utm_campaign=DTR+-+Industry+Insight+-+Bio-Techne+-+Organoids+-+06.05.22&utm_term=Scientists+create+brain+organoids+to+understand+autism&utm_content=https%3a%2f%2femails.drugtargetreview.com%2frussellpublishinglz%2f&gator_td=iX%2fmyVj91S%2bc2AyEjDjndS54EdMTesGaKMuZ4EfTMrjCZqIuHPp1NM%2fECg5vRjnqMeg1VwiF075MHH6op2UThSOimHJsibguToBpnlqGrJznkyrQdg1%2fDMZDirmrtFJgxPyhWvSPENn%2fp7nYv%2fU%2fLx%2bvc3yGDLX7GhCLAciG1lj0V5zG9qjyGhjpi6J%2fc3IF13KIVtlA971fX68r7kTc5dz99cRPLSa3Rv1yzyQ%2fpyZXASq%2b0KH9q4IijF74RVvN
