3D bioprinted vascularized breast tumor model
October 2022
Penn State University, University Park, USA
Despite substantial advancements in the development of cancer treatments, the lack of standardized and physiologically-relevant in vitro testing platforms limit the early screening of anticancer agents. A major barrier is the complex interplay between the tumor microenvironment and immune response. To tackle this, a dynamic-flow-based 3D bioprinted multi-scale vascularized breast tumor model, responding to chemo and immunotherapeutics was developed. Heterotypic tumors were precisely bioprinted at pre-defined distances from a perfused vasculature, exhibiting tumor angiogenesis and cancer cell invasion into the perfused vasculature. Bioprinted tumors treated with varying dosages of a chemotherapy medication portrayed a dose-dependent drug response behaviour. Furthermore, a cell-based immune therapy approach was explored, resulting in up to ≈70% reduction in tumor volumes. The presented platform paves the way for a robust, precisely fabricated, and physiologically-relevant tumor model for the future translation of anti-cancer therapies to personalized medicine.
Chemotherapeutics and CAR-T cell-based immunotherapeutics screening on a 3D bioprinted vascularized breast tumor model
Ibrahim T. Ozbolat
Added on: 11-25-2022
[1] https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.202203966[2] https://www.drugtargetreview.com/news/105864/ground-breaking-3d-bioprinted-tumours-aid-immunotherapy-research/?utm_source=Email+marketing&utm_medium=email&utm_campaign=DTR+-+Industry+Insight+-+Bio-Techne+-+Immuno-oncology+-+18.11.2022&utm_term=Ground-breaking+3D+bioprinted+tumours+aid+immunotherapy+research&utm_content=https%3a%2f%2femails.drugtargetreview.com%2frussellpublishinglz%2f&gator_td=OMA0rHzjg6UQ7dN3i4iJQEulw%2bMTp8AUlCWkCPt44RDzGgZz66fhfl2fTz0z6tXvZA7lSIXyMi25Rkz8R9partCCkYs6azRL1Am2evVmwDWYW2Ib576neL7pJTTVgY2gg202vfGIihU6K38GWHnskEBhJITgfMwbS%2fOnSjGPJpGPZHqVrzfHMHPt4LPWC4QgXHPoeoIMgzjt2ERlcFCwk2fhgO%2bm%2fLS2moOD8dYHdwoOT316HNvEHHPVckOxNMRyqOfLuj68DhFBmQztf0Hfrw%3d%3d
