Mapped protein structure of Hepatitis C could lead to vaccine
October 2022
The Scripps Research Institute, La Jolla, USA(1)
University of Amsterdam, Amsterdam, Netherlands(2)
University of Amsterdam, Amsterdam, Netherlands(2)
The hepatitis C virus (HCV) causes chronic infection of the liver that can lead to cirrhosis or liver cancer. A prophylactic vaccine could ameliorate these long-term consequences for millions of people, but vaccine development is hampered by the lack of structural information on the vaccine target, a glycoprotein complex located on the surface of the virus. In this study, the researchers determined the cryo-electron microscopy structure of the envelope glycoprotein E1E2 heterodimer in a complex with three broadly neutralizing antibodies. The structure elucidates how the two subunits interact, describes three key neutralizing epitopes, and provides a blueprint for the design of vaccines and drugs that target HCV.
Structure of the hepatitis C virus E1E2 glycoprotein complex
Andrew B. Ward(1), Rogier W. Sanders(2), Kwinten Sliepen(2)
Added on: 11-25-2022
[1] https://www.science.org/doi/10.1126/science.abn9884[2] https://www.drugtargetreview.com/news/105922/mapped-protein-structure-of-hepatitis-c-could-lead-to-vaccine/?utm_source=Email+marketing&utm_medium=email&utm_campaign=DTR+-+Industry+Insight+-+Takara+Bio+-+Vaccine+Development+-+28.10.2022&utm_term=Is+an+HIV+vaccine+on+the+horizon%3f+%0d%0d+&utm_content=https%3a%2f%2femails.drugtargetreview.com%2frussellpublishinglz%2f&gator_td=6KGMDCP5YJ8uR3PEbBOhTQFpP9x8iqAMlW3e1J5JZwsXNxJPQDQ4%2fF%2blFkkE9PTABVePPVZ6Oh7pc2%2f%2fYvjejrRP7hCUl1F9A7D9Yf0CQk7VeKPOla36ZRxd4USUnJsGzeW%2by3bVnUm2y%2bsgQ4K4sn29H3i60zUp5KzqM7XgxDS%2bhyQ20drmjn%2fcuHcenw3kCXVcPNvjbiQoitu0Q2FWJML512pqcDilJZUzqRZlgJY0wOtbtIhq6G%2b1H3pyzrmaRC7OfOyOjOsJmFXDm62dFw%3d%3d
