Liquid pearls method for drug testing against pancreatic tumors
Company 2022
Université de Strasbourg, Illkirch, France
In this study, human pancreatic tumor cell lines were used to identify compounds with anticancer activity. So-called liquid pearls were produced, in which human pancreatic chemo-resistant cells were injected. Within the pearls, cancer organoids were formed and challenged with cannabis extracts that were injected directly into the pearls. Different plant extracts were used and corresponding inhibitory concentration (IC50) values were determined, compounds exhibiting anticancer activity were identified, and the mechanism of action for apoptosis induction was studied. The results were compared with those obtained with Gemcitabine, a drug widely used in patients with pancreatic cancers. While gemcitabine only triggers cell cycle arrest, the cannabinoid extract also activates the cell signalling cascade leading to programmed cell death.
The results emphasize the potential of natural products for pancreatic cancer therapy and demonstrate the applicability of liquid pearl technology for drug screening processes.
Cannabis sativa extract induces apoptosis in human pancreatic 3D cancer models: Importance of major antioxidant molecules present therein
Christian D. Muller
Added on: 11-24-2022
[1] https://www.mdpi.com/1420-3049/27/4/1214[2] https://pearlbiosystem.com/
