Immunotherapy method to find antigens that trigger specific T cells
2022
Stanford University, Stanford, USA
Adaptive immunity relies on T lymphocytes that use T cell receptors (TCRs) to discriminate among peptides presented by major histocompatibility complex molecules (pMHCs). T-cell recognition of sparse antigenic pMHCs in vivo relies on biomechanical forces. However, in vitro screening methods test potential pMHCs without force and often at high (nonphysiological) pMHC densities and thus fail to predict potent agonists in vivo. Here, the researchers present a technology termed BATTLES (biomechanically assisted T cell triggering for large-scale exogenous-pMHC screening) that uses biomechanical force to initiate T cell triggering for peptides and cells in parallel. BATTLES can be used to explore basic T cell mechanobiology and T cell-based immunotherapies.
A bead-based method for high-throughput mapping of the sequence- and force-dependence of T cell activation
Polly M. Fordyce
Added on: 10-25-2022
[1] https://www.nature.com/articles/s41592-022-01592-2[2] https://www.drugtargetreview.com/news/104836/new-immunotherapy-to-find-antigens-that-trigger-specific-t-cells/?utm_source=Email+marketing&utm_medium=email&utm_campaign=DTR+-+Industry+Insight+-+Bio-Techne+-+Immuno-Oncology+-+16.09.22&utm_term=Findings+on+pancreatic+cancer+could+improve+immunotherapies+&utm_content=https%3a%2f%2femails.drugtargetreview.com%2frussellpublishinglz%2f&gator_td=YYCe1ZeSG%2brG4khnjb9JILlmmmQuJYq5Z5KEdohdl7MiOMNMUVM9uuvNdzuasDg0IOmBHVSzT2s0fNmsm4dpkqEjfUUVbRRR0fhtOKoWViSXy6eNmfeR5z06IeNqWSLsZi37coWquxxRaZnTXmO2mtd7TXBJEcm9U6k5swqhjwYm8o1X5qF7C4w9H2WhnKLTiVodpSN552N7m6QeLTwFcycGaGU75EL4e7c%2fD3Tk2XriN5gQR56Y8A7m8yHcVVzhiTTmdauc7fvgDI%2bVi5qwWw%3d%3d
