Studying human neural development is challenging as samples are rare and difficult to obtain. A new and reliable model for neural tube morphogenesis was developed using the self-organizing properties of human pluripotent stem cells, directed by micropatterning on an organ-on-a-chip device and minimal morphogenetic compounds. The researchers could recapitulate neural tube closure, the developing neuroectoderm, and neural crest and surface ectoderm populations with proper migration patterns. This tool offers exciting perspectives for neural tube defect modelling.
Human neural tube morphogenesis in vitro by geometric constraints
Added on: 10-25-2022
[1] https://www.nature.com/articles/s41586-021-04026-9#citeas
