Role of specific microbiotics in asthma and COPD investigated using sputum samples
2022
Third Military Medical University, Chongqing, China
Studies of chronic inflammatory airway diseases have increasingly focused on the airway microbiota. However, the microbiota characteristics of patients with asthma and chronic obstructive pulmonary disease (COPD) with different airway inflammatory phenotypes remain unclear. The aim of this study was to reveal the differences in fungal and bacterial microbiota between patients with eosinophilic asthma (EA) and non-eosinophilic asthma (NEA) and between patients with eosinophilic COPD (EC) and non-eosinophilic COPD (NEC). Sputum samples were collected from 45 asthma patients and 39 COPD patients, and RNA-seq analysis was performed.
Different airway inflammatory phenotypes were associated with specific fungal and bacterial microbiota in both asthma and COPD, while the same airway inflammatory phenotype showed some similarity in the airway microbiota, especially in the fungal microbiota.
The results indicated that mycotic and bacterial microbiota are associated with a specific airway inflammatory state, and revealed the concordance of different microbiota characteristics in certain phenotypes in patients with asthma and COPD. This could be significant for further research into disease pathogenesis and the development of potential targeted therapies.
Different airway inflammatory phenotypes correlate with specific fungal and bacterial microbiota in asthma and chronic obstructive pulmonary disease
Qianli Ma
Added on: 03-30-2022
[1] https://www.hindawi.com/journals/jir/2022/2177884/
