Fetal origin of chronic obstructive pulmonary disease investigated using tissue samples
2022
Harvard Medical School, Boston, USA
In utero exposures such as cigarette smoking and perturbed lung growth and development are associated with chronic obstructive pulmonary disease (COPD), but little is known about molecular links between early exposures, lung growth, and adult-onset disease.
In this study, lung tissue from human fetuses was exposed to cigarette smoke and subsequently subjected to genetic analysis. In addition, lung tissue from COPD patients was examined. Network modules were identified and connectivity between fetal lung DNA methylation and COPD DNA methylation and expression modules was investigated. Using these modules, biological mechanisms and common signalling pathways were highlighted, including the AGE-RAGE pathway, which may provide molecular links between lung development and COPD.
Protein interaction networks provide insight into fetal origins of chronic obstructive pulmonary disease
Annika Röhl
Added on: 03-30-2022
[1] https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-022-01963-5
