A potential new way of preventing Alzheimer’s disease
2022
Laval University, Quebec, Canada
Toxic β-amyloid peptides induce neuron death, memory problems, and Alzheimer's disease (AD) development. Several amyloid precursor protein (APP) mutations increase the risk of developing early-onset AD. However, the A673T mutation identified in the Icelandic population prevents AD development by reducing the cleavage of APP by β-secretase. In this study, the researchers inserted the A673T mutation in human cells using the CRISPR prime editing (PE) technique. They show that PE is a promising approach for introducing the A673T mutation precisely without mutating nearby nucleotides.
Insertion of the Icelandic mutation (A673T) by prime editing: a potential preventive treatment for familial and sporadic Alzheimer's disease
Jacques P. Tremblay
Added on: 03-10-2022
[1] https://www.liebertpub.com/doi/10.1089/crispr.2021.0085[2] https://www.drugtargetreview.com/news/101375/research-provides-potential-new-way-of-preventing-alzheimers-disease/?utm_source=Email+marketing&utm_medium=email&utm_campaign=DTR+-+Newsletter+8+-+Sino+Biological+-+24.02.2022&utm_term=Research+provides+potential+new+way+of+preventing+Alzheimer%e2%80%99s+disease&utm_content=https%3a%2f%2femails.drugtargetreview.com%2frussellpublishinglz%2f&gator_td=WG0%2bsOR34bUhl%2bqMEMjTgc1BfBFndf9zbcU4nZAFYOWC5W0NaUtGDE1ToCQpGnRSFYQRt5PuRzDUBLtL14kvl5ySMLz2On8oyzEFw02rZHbpIIEV%2bR4LnjWVgdjEWA09MSrLiIOZ1jb5mNcR2Hl1iuvw7p3TUtbsTCiEqQvrzQi0IdEtEbRNfgvC1%2bKJSLQ%2fkgUR1E%2biE4AX6qU%2ft2y2A5h1FvXYsmjD0wrVfIDCK1x6eCQkWXkd4l6v%2fsLF42jo
