Role of microRNAs in lung cancer
October 2021
Technische Universität Darmstadt, Darmstadt, Germany
Intercellular communication plays an essential role in lung cancer. One essential component in this communication are microRNAs (miRs), whose transport has recently attracted increasing research interest. It is known that most cases of non-small cell lung cancer are associated with an overexpression of the pro-inflammatory lipid mediator prostaglandin E2 (PGE2) which strongly promotes tumour growth. Using human lung tumour tissue, cancer cell lines and spheroid cultures, the researchers were able to demonstrate for the first time in this study that PGE2 significantly increases the exosomal secretion of microRNA miR-574-5p in lung cancer cells. This newly discovered relationship between miR-574-5p and PGE2 opens up new therapeutic possibilities for lung cancer.
Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer
Meike J. Saul
Added on: 02-23-2022
[1] https://onlinelibrary.wiley.com/doi/10.1002/jev2.12143[2] https://www.bionity.com/en/news/1173119/a-small-molecule-controls-lung-cancer.html
