New microRNA linked to coronary artery disease characterized in cultured human cells
2018
Fujian Medical University Union Hospital, Fuzhou, China
Coronary artery disease (CAD) is the main cause of death and disability worldwide. MicroRNAs (miRNAs) are small, noncoding RNAs that regulate gene expression at the post-transcriptional level, some circulating miRNAs have been reported that could monitor several cardiovascular disease processes. One miRNA of interest is miR-574-5p which expression is notably increased in the sera of patients with CAD. In the present study, the researchers aimed at gaining knowledge on the specific mechanisms by which miR-574-5p affects CAD. The researchers isolated sera from CAD patients and detected an increased expression level of miR-574-5p. Vascular smooth muscle cells (VSMCs) are known to have aberrant proliferation in CAD. Also, miR-574-5p was introduced into VSMCs cultured in vitro which resulted in increased cell proliferation and inhibited apoptosis. Further, the researchers showed that miR-574-5p in those cells specifically regulated a gene called ZDHHC14 which has been traditionally linked to cancer. Overall the study reveals miR-574-5p as a potential target for CAD treatment.
MicroRNA-574-5p promotes cell growth of vascular smooth muscle cells in the progression of coronary artery disease
Liangcheng Zhang
Added on: 11-29-2021
[1] https://www.sciencedirect.com/science/article/pii/S0753332217339148?via%3Dihub[2] https://data.jrc.ec.europa.eu/dataset/20947a04-86ef-473f-8907-c658e4050c24
