CD133+ differentiation plasticity in chronic obstructive pulmonary disease
2007
Universitat de Barcelona, Barcelona, Spain
Several studies have shown that CD133+ bone marrow-derived endothelial progenitor cells can infiltrate pulmonary arteries in patients with chronic obstructive pulmonary disease and differentiate into smooth muscle cells. Here, isolated human pulmonary arteries together with co-cultures of human pulmonary artery endothelial and smooth muscle cells were co-incubated with CD133+ cells to evaluate their capacity to differentiate into endothelial or smooth muscle cells. The results showed that CD133+ cells modify their morphology and phenotype to adapt to the cells present in the co-culture assays and differentiated into smooth muscle cells in isolated pulmonary arteries. Moreover, it was observed that cell differentiation was done through transdifferentiation rather than cell fusion. Overall, the researchers confirm the differentiation plasticity of CD133+, reinforcing the idea of their critical role in pulmonary artery remodelling in chronic obstructive pulmonary disease.
Plasticity of CD133+ cells: Role in pulmonary vascular remodeling
Victor I Peinado
Added on: 11-27-2021
[1] https://academic.oup.com/cardiovascres/article/76/3/517/488218#7446140[2] https://data.jrc.ec.europa.eu/dataset/176d71e6-5082-4b29-8472-b719f6bda323
