Human cerebral organoids for the analysis of neuronal heterotopia
2019
Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany(1)
Max Planck Institute of Psychiatry, München, Germany(2)
Max Planck Institute of Psychiatry, München, Germany(2)
The authors study periventricular heterotopia (PH) by analyzing cerebral organoids derived from iPSCs of patients with certain mutations or from isogenic knockout lines. Cerebral organoids reproduce the cortical heterotopia associated with PH and a single-cell RNA-sequencing approach reveal a subpopulation of mutant neurons with dysregulated genes involved in axon guidance, neuronal migration and patterning. A defective neural progenitor cell morphology and an altered navigation system in a subset of neurons can, therefore, underlie this form of PH.
Altered neuronal migratory trajectories in human cerebral organoids derived from individuals with neuronal heterotopia
Barbara Treutlein(1), Silvia Cappello(2)
Added on: 05-25-2020
[1] https://www.nature.com/articles/s41591-019-0371-0
