Factors controlling immune cells studied in cells isolated from patients with multiple sclerosis
November 2018
Rafsanjan University of Medical Sciences, Rafsanjan, Iran
Multiple Sclerosis (MS) results in the demyelination of neurons within the brain and spinal cord due to inflammatory and autoimmune reactions. The disease is caused by self-reactive Th1 lymphocytes, while Th2 cells may confer protection. Both cell types, Th1 and Th2, are derived from the same naïve cells in a process controlled by specific cellular transcription factors called T-bet and GATA-3. In the present study, the researchers aimed at uncovering the T-bet and GATA-3 expression level in immune cells isolated from MS patients. The data show that the T-bet expression was enhanced, while the GATA-3 expression diminished. These results probably indicate an imbalance in Th1/Th2 cells in the level of transcription factors with a tendency toward Th1 cells in MS. The clinical utilization of the transcription factors as novel biomarkers of MS should be evaluated in further studies.
Different expressions of specific transcription factors of Th1 ( T-bet) and Th2 cells ( GATA-3) by peripheral blood mononuclear cells from patients with multiple sclerosis
Abdollah Jafarzadeh
Added on: 10-30-2021
[1] http://bcn.iums.ac.ir/article-1-744-en.html[2] https://data.jrc.ec.europa.eu/dataset/700397b2-edd7-4ed6-86f7-fc1b164ed432
