Role of a neuropeptide in inflammation studied on primary and immortalized human cells
2015
University of Nottingham, Nottingham, United Kingdom
Substance P (SP) is a neuropeptide that shows properties comparable to cytokines and exerts different effects in autoimmune inflammation. SP and its neurokinin-1 receptor (NK1R) are expressed by various immune cells and their role has been demonstrated in autoimmune conditions like multiple sclerosis (MS). In the present study, the researchers aimed at better understanding the role of SP and NK1R in human immune cells and their relationship with a number of cytokines. The researchers performed a number of in vitro analyses on primary immune cells isolated from donors and of human immortalized immune cell lines. The cells were treated with SP or cytokines and levels of expression of each component were assessed. Mutual interactions exist with SP enhancing the cytokines, and SP and NK1R expression being differentially but potentially synergistically regulated by these cytokines. The data suggest a proinflammatory role for SP in autoimmune inflammation, probably stimulating the recruitment of immune cells. In conclusion, SP may be a therapeutic target in MS.
Reciprocal regulation of substance P and IL-12/IL-23 and the associated cytokines, IFNγ/IL-17: a perspective on the relevance of this interaction to multiple sclerosis
Cris S. Constantinescu
Added on: 10-30-2021
[1] https://link.springer.com/article/10.1007%2Fs11481-015-9589-x[2] https://data.jrc.ec.europa.eu/dataset/700397b2-edd7-4ed6-86f7-fc1b164ed432
