Role of regulatory T cells in myasthenia gravis studied using patients' cells
2017
Istanbul University, Istanbul, Turkey
Myasthenia gravis (MG) is the most common humoral and cellular immune-mediated neuromuscular disorder, caused by autoantibodies against the acetylcholine receptor of skeletal muscles. Regulatory T cells (Treg) are an essential component in the counterbalance of the autoimmune response by regulating the activation, proliferation and cytokine production of autoreactive cells. In the present study, the researchers aimed at investigating cytokine-related mechanisms that may lead to the defect of Treg in patients with MG. T cells were isolated from patients and tested in vitro for their capacity for suppression of immune response. The results show an impaired immune regulation in patients with MG which is associated with changes in cytokine production. The findings suggest that MG should be considered among candidate diseases for cytokine-based immunotherapy approaches.
The effect of interleukin (IL)-21 and CD4+CD25++ T cells on cytokine production of CD4+ responder T cells in patients with myasthenia gravis
G. Saruhan-Direskeneli
Added on: 10-29-2021
[1] https://onlinelibrary.wiley.com/doi/10.1111/cei.13006[2] https://data.jrc.ec.europa.eu/dataset/700397b2-edd7-4ed6-86f7-fc1b164ed432
